The TS2/9 monoclonal antibody binds specifically to CD58, a 45–70 kDa cell surface glycoprotein in the immunoglobulin superfamily. CD58 is also known as lymphocyte function-associated antigen 3 (LFA-3). CD58 is the receptor for the ligand CD2, it mediates cellular adhesion and participates in signal transduction when it binds to CD2. The CD58/CD2 interaction has been reported to play a role in regulating the antigen-independent adhesion pathway and cytotoxic T lymphocyte (CTL) activity. CD58 is expressed on a variety of both hematopoietic and nonhematopoietic cells including B cells, T cells, monocytes, erythrocytes, endothelial cells, epithelial cells, and fibroblasts.
Anti-Human CD58 (TS2/9)-176Yb—100 Tests