Programmed death 1 (PD-1), also known as CD279, is a 55 kDa member of the CD28 immunoglobulin superfamily expressed on activated T cells, B cells, dendritic cells and macrophages. Engagement of PD-1 inhibits function in these immune cell subsets. PD-1 has two known counterreceptors or ligands, B7-H1 (CD274, PD-L1) and B7-DC (CD273, PD-L2). PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic domain. The PD-1/B7-H1 pathway has emerged as playing a pivotal role in the negative regulation of T cell activity, including suppression of immune responses against cancer.
Anti-Human CD279/PD-1 (EH12.2H7)-174Yb—100 Tests