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Anti-Cleaved Caspase 3 (5A1E)-172Yb—25 µg

Caspase-3 (CPP32/Yama/apopain) is a 32 kDa cysteine protease that is activated during the early stages of apoptosis. Activation of caspase-3 requires proteolytic processing of its inactive zymogen into activated p17 and p12 fragments, which associate to form the active enzyme. Caspase-3 is either partially or totally responsible for the proteolytic cleavage of many key proteins in the apoptotic pathway, such as the nuclear enzyme poly (ADP-ribose) polymerase (PARP). Caspase-3 expression is widely distributed. Cells of lymphoid origin express high levels, and active caspase-3 is a marker for cells undergoing apoptosis. Caspase-3 also plays an important role in morphogenetic cell death during development of the mammalian brain. The 5A1E antibody reacts with the active cleaved form of caspase-3.

  • Species:
    Cross
  • Clone:
    5A1E
  • Target:
    Caspase-3 cleaved
  • Tag:
    172Yb

 

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