CD80 (B7-1) is a 60 kDa member of the B7 family of proteins. CD80 is constitutively expressed on dendritic cells and monocytes/macrophages and inducibly expressed on T and B cells. While CD80 can bind to the immune-stimulatory CD28, it binds with higher affinity to the immune-inhibitory CTLA-4. The B7 ligands CD80 and CD86 and their receptors CD28 and CTLA-4 create a co-stimulatory, co-inhibitory system that acts to regulate immune responses. Mice deficient in CD80 and CD86 have profound defects in both humoral and cellular immunity.
Anti-Mouse CD80 (16-10A1)-171Yb—100 Tests