T-bet (Tbx-21) is a transcription factor bearing a T-box DNA-binding domain. It is considered a master-regulator of the Th1 CD4+ T cell subset. T-bet was initially described as a potent transactivator that can promote IFNγ production by initiating Th1 lineage development from naïve CD4+ T cells. T-bet specifies Th1 cell fate by initiating chromatin/histone remodeling of the IFNγ gene and by inducing IL-12 receptor β2 expression. T-bet also promotes the Th1 phenotype by actively suppressing Th2 differentiation by interfering with GATA-3-binding to its target DNA. In addition to T cells, T-bet is expressed in B cells, where it plays a role in class-switch recombination.
Anti-Human/Mouse Tbet (4B10)-160Gd—100 Tests