The HIM6 monoclonal antibody specifically binds to CD147, a 55–65 kDa type I transmembrane glycoprotein that is also known as neurothelin or basigin. CD147 is broadly present on both hematopoietic and nonhematopoietic cells. It is primarily expressed on leukocytes, erythrocytes, platelets, and endothelial cells. CD147 has been reported to play a role in embryonal blood-brain barrier development and to be involved in integrin-mediated adhesion in brain endothelia.
Anti-Human CD147 (HIM6)-156Gd—100 Tests