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Anti-Human CD279/PD-1 (EH12.2H7)-155Gd—100 Tests

Programmed death 1 (PD-1), also known as CD279, is a 55 kDa member of the CD28 immunoglobulin superfamily expressed on activated T cells, B cells, dendritic cells, and macrophages. Engagement of PD-1 inhibits function in these immune cell subsets. PD-1 has two known counter receptors or ligands, B7-H1 (CD274, PD-L1) and B7-DC (CD273, PD-L2). PD-1 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in its cytoplasmic domain. The PD-1/B7-H1 pathway has emerged as playing a pivotal role in the negative regulation of T cell activity, including suppression of immune responses against cancer.

  • Species:
    Human
  • Clone:
    EH12.2H7
  • Target:
    CD279/PD-1
  • Tag:
    155Gd

 

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