T cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3) is a type I transmembrane receptor that is constitutively expressed at high levels on NK cells. It is also expressed on specific subsets of CD4+ and CD8+ T cells, on subpopulations of macrophages and DCs and on monocytes, albeit to a lesser extent than on NK cells. TIM-3 was originally identified as a marker of terminally differentiated CD4+ Th1 cells and subsequently associated with T cell exhaustion and impaired virus-specific T cell responses in HIV-1, hepatitis C virus (HCV) and hepatitis B virus (HBV) infection. Three ligands have been described for TIM-3: galectin-9 (Gal-9), cell surface phosphatidylserine and the high-mobility group box 1 (HMGB1) protein. Gal-9 is highly expressed in immune tissues, and engagement of TIM-3 by Gal-9 triggers apoptosis in CD4+ Th1 cells, T cells and thymocytes. TIM-3 signaling on immune cells can trigger either inhibitory or activating signals.
Anti-Human CD366/TIM-3 (D5D5R)-154Sm—25 µg