CD194, also known as CCR4 (CC chemokine receptor type 4), belongs to the G protein-coupled receptor family. It is expressed on stimulated and unstimulated T and B cells, basophils, monocytes, and NK cells. Human peripheral blood Tregs can be divided into two distinct populations based on the expression of CCR4. Freshly isolated Tregs express CCR4 and presumably represent memory-type Tregs, and CCR4(-) Tregs require anti-CD3 antibody-mediated activation to acquire a regulatory activity. Depletion of CCR4(+) T cells leads to Th1-type polarization of CD4(+) T cells and augmentation of CD8(+) T cell responses to tumor antigens.
Anti-Human CD194/CCR4 (205410)-153Eu—50 Tests