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Anti-Human TIM-3 (F38-2E2)-153Eu—100 Tests

T cell immunoglobulin and mucin domain-containing molecule 3 (TIM-3) is a type I transmembrane receptor that is constitutively expressed at high levels on NK cells. It is also expressed on specific subsets of CD4+ and CD8+ T cells, on subpopulations of macrophages and DCs, and on monocytes, albeit to a lesser extent than on NK cells. TIM-3 was originally identified as a marker of terminally differentiated CD4+ Th1 cells, and subsequently associated with T cell exhaustion and impaired virus-specific T cell responses in HIV-1, hepatitis C virus (HCV) and hepatitis B virus (HBV) infection. Three ligands have been described for TIM-3, including galectin-9 (Gal-9), cell surface phosphatidylserine, and the high-mobility group box 1 (HMGB1) protein. Gal-9 is highly expressed in immune tissues, and engagement of TIM-3 by Gal-9 triggers apoptosis in CD4+ Th1 cells, T cells, and thymocytes. TIM-3 signaling on immune cells can trigger either inhibitory or activating signals.

  • Species:
    Human
  • Clone:
    F382E2
  • Target:
    TIM-3
  • Tag:
    153Eu

 

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