The T cell receptor (TCR) is a heterodimer consisting of an α and a β chain (TCR α/β) or a γ and a δ chain (TCR γ/δ). In approximately 95% of T cells, the TCR consists of α/β chain, whereas in 5% of T cells it consists of γ/δ chains. TCR γ/δ is involved in the recognition of certain bacterial, self-CD1 molecule, and tumor antigens bound to MHC class I. TCRγ/δ associates with CD3 and is expressed on a subset of T cells found in the thymus, the intestinal epithelium, and the peripheral lymphoid tissues and peritoneum. Most γ/δ T cells are CD4-/CD8-, but some are CD8+. Antibody clone B1 recognizes a cell surface epitope of the TCR γ/δ complex.
Anti-Human TCRgd (11F2)-152Sm—100 Tests