The C40-1457 monoclonal antibody specifically binds to the nerve growth factor receptor (NGFR), also known as CD271. CD271 is 75 kDa type I transmembrane glycoprotein known as TNFRSF16 that belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD271 has been found localized to neuronal axons, Schwann cells, and perineural cells of peripheral nerves and is also expressed in some epithelial, mesenchymal, and lymphoid tissues. NGFR is the receptor for nerve growth factor (NGF), a polypeptide that is essential for normal development of the nervous system. NGF binds to 2 distinctive surface receptors, the p/140 (proto-TRK) and p75 (NGFR). NGF promotes survival and differentiation of sympathetic and sensory neurons during embryological development of the peripheral nervous system. There is evidence that NGFR interaction with its ligand, NGF, may play a role in immunoregulation. It has also been reported that NGF may function as a B cell growth factor.
Anti-Human CD271 (C40-1457)-149Sm—100 Tests