SOX9 (sex determining region Y-box 9), a transcription factor associated with the testis-determining factor sex determining region Y (SRY), consists of two functional domains: a high-mobility group (HMG) DNA-binding domain and a C-terminal transactivation domain. It is expressed mainly in adult tissues and also in fetal testis and skeletal tissue. SOX9 plays a major role in cartilage differentiation and early testis development. Recent research has shown that SOX9 expression in lung adenocarcinoma induces a mesenchymal phenotype in tumor cells. In addition, SOX9 expression has been linked with several other tumor types including ovarian, prostate and pancreatic malignancies.
Anti-SOX9 (EPR14335)-147Sm—25 µg