Vimentins are type III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. They are highly expressed in fibroblasts, with low expression in T and B lymphocytes and little or no expression in Burkitt's lymphoma cell lines. They are also expressed in many hormone-independent mammary carcinoma cell lines. Dynamic structural changes and spatial reorganization of vimentin in response to extracellular stimuli help to coordinate various signaling pathways. Remodeling of vimentin and other intermediate filaments is important during lymphocyte adhesion and migration through the endothelium.
Anti-Vimentin (D21H3)-143Nd—25 µg