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Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model

Bard-Chapeau, E.A., Nguyen, A.T., Rust, A.G., et al.

The most common risk factor for developing hepatocellular carcinoma (HCC) is chronic infection with hepatitis B virus (HBV). To better understand the evolutionary forces driving HCC we performed a near saturating transposon mutagenesis screen in a mouse HBV model of HCC. This screen identified 21 candidate early stage drivers, and a bewildering number (2860) of candidate later stage drivers, that were enriched for genes mutated, deregulated, or that function in signaling pathways important for human HCC, with a striking 1199 genes linked to cellular metabolic processes. Our study provides a comprehensive overview of the genetic landscape of HCC.

Citation

Bard-Chapeau, E.A., Nguyen, A.T., Rust, A.G., et al. "Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model" Nature Genetics (2014): 24–32