中国

Publications

Single-cell gene profiling analysis of human regulatory T cell subsets

Maiella, S., Dong, S., Becavin, C., Coffre, M., Placek, K., Bianchi, E., Benecke, A., Rogge, L.

Negative regulation of the immune system is of critical importance to prevent pathology. This level of regulation is compromised in autoimmunity and graft-versus-host disease, a life-threatening complication of hematopoietic stem cell transplantation. CD4+CD25+FOXP3+ regulatory T cells (Treg) are potent suppressors of these adverse immune reactions. Treg also play critical roles in the maintenance self-tolerance and the control of immune homeostasis. Recent reports have suggested that human Treg cells may not be a homogenous cell population.

The aim of this study was to identify and characterize human Treg sub-populations.

Citation

Maiella, S., Dong, S., Becavin, C., Coffre, M., Placek, K., Bianchi, E., Benecke, A., Rogge, L. "Single-cell gene profiling analysis of human regulatory T cell subsets" Journal of Translational Medicine (2010): P3