Profiling of coexpression of multiple immune checkpoints in the CD4+ and CD8+ T cell components of the clear cell renal cell carcinoma immune infiltrate
Monette, A., Al-Banna, N., Routy, J.P., Lapoint, R.
Immune checkpoint blockade therapies have been proven to elicit clinical responses in clear cell renal cell carcinoma (ccRCC) patients. A comprehensive profiling of the tumor landscape is however still required and will help to explain how for this cancer, the high densities of infiltrating CD8+ T cells have previously been correlated with a poor clinical outcome. Studies analyzing the tumor immunome often examine gene expression from the complete specimen, which is an overlap of expression profiles from the many different cell types from this microenvironment, and which may make results difficult to interpret. Therefore, we aimed to profile and validate the gene expression signatures from individual CD4+ and CD8+ immune cell subsets isolated from freshly resected ccRCC patient tumors and blood for their comparison to those from normal kidney tissues and blood, respectively.
Monette, A., Al-Banna, N., Routy, J.P., Lapoint, R. "Profiling of coexpression of multiple immune checkpoints in the CD4+ and CD8+ T cell components of the clear cell renal cell carcinoma immune infiltrate" Journal for Immunotherapy of Cancer (2015): P272