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Product Focus: Analytical and Preparative Instrumentation

Taylor, P.

According to Fluidigm, its new BioMark HD System is designed to deliver the sensitivity and throughput needed to study gene expression down to the single-cell level—especially with limited amounts of sample or rare populations of cells. By incorporating a new fast thermal cycling protocol, the BioMark HD System reduces time-to-result by increasing the throughput of the original system twofold. Users now have the ability to generate more than 50 000 data points in one day with only one user. The fast thermal cycling protocol is compatible with commercially available assays and yields data that are equal in quality to standard cycling protocol data. The BioMark HD platform continues to use Fluidigm’s nanofluidic technology and supports all the applications of the original BioMark System, including gene expression, single-cell gene expression, and genotyping. Using Digital Array chips, the BioMark HD System performs common digital PCR applications, such as mutation detection, copy number variation, and absolute quantitation of nucleic acid sequences.

Citation

Taylor, P. "Product Focus: Analytical and Preparative Instrumentation" Journal of Biomolecular Sceening (2012): 121–3