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Polymer-Based Elemental Tags for Sensitive Bioassays

Lou, X., Zhang, G., Herrera, I. et al.

It's elemental: A water-soluble polymer bearing multiple metal-chelating ligands has been used as a tag for bioassays with inductively coupled plasma mass spectrometry. The tag was covalently conjugated to antibodies, and the polymer–antibody constructs were loaded with lanthanide ions (Ln3+) and used for the simultaneous assay of five orthogonally labeled antibodies against cell surface antigens that differ in abundance by more than two orders of magnitude.

Citation

Lou, X., Zhang, G., Herrera, I. et al. "Polymer-Based Elemental Tags for Sensitive Bioassays" Angewandte Chemie (2007): 6,111–4