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Oscope identifies oscillatory genes in unsynchronized single-cell RNA-seq experiments

Leng, N., Chu, L.F., Barry, C., et al.

Oscillatory gene expression is fundamental to mammalian development, but technologies to monitor expression oscillations are limited. We have developed a statistical approach called Oscope to identify and characterize the transcriptional dynamics of oscillating genes in single-cell RNA-seq data from an unsynchronized cell population. Applications to a number of data sets demonstrate the utility of the approach and also identify a potential artifact in the Fluidigm C1 platform.

Citation

Leng, N., Chu, L.F., Barry, C., et al. "Oscope identifies oscillatory genes in unsynchronized single-cell RNA-seq experiments" Nature Methods (2015): 947–50