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High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia

Wierz, M., Janji, B., Berchem, G. et al.

The progression of chronic lymphocytic leukemia (CLL), the most frequent leukemia in adults, is highly dependent on complex interactions with cells populating the CLL tumor microenvironment (TME), which is associated with dysfunctional anti-tumor immunity. To escape surveillance by the immune system, tumor cells are able to co-opt multiple immunosuppressive pathways such as the engagement of immune checkpoints that prevents an effective anti-tumor immunity. Immunotherapy aims to stimulate anti-tumor activity by reactivating the immune system. Recently, immune checkpoints blockade showed promising results in a mouse preclinical model of CLL. Despite recent advances in treatments, CLL remains an incurable disease. Therefore, finding specific targets and combining immunotherapy approaches represent new challenges for efficient CLL treatment.

Citation

Wierz, M., Janji, B., Berchem, G. et al. "High-dimensional mass cytometry analysis revealed microenvironment complexity in chronic lymphocytic leukemia" OncoImmunology (2018): e1465167