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Fluidigm Dynamic Arrays provide a platform for single-cell gene expression analysis

Pieprzyk, M., High, H.

Historically, single-cell gene expression experiments have been difficult and expensive to perform. Now, however, single-cell gene expression results from single-cell samples can be inexpensive and easily reproducible using Fluidigm's Dynamic Array™ integrated fluidic circuits and BioMark™ system for genetic analysis. This method is ideally suited for high-throughput cell-line studies to determine individual cell behavior in a homozygous population. To demonstrate this capability, we chose single human cells from eight-cell-stage embryos, collected and analyzed for expression of 46 developmental genes.

Citation

Pieprzyk, M., High, H. "Fluidigm Dynamic Arrays provide a platform for single-cell gene expression analysis" Nature Methods (2009):