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Design and computational analysis of single-cell RNA-sequencing experiments

Bacher, R., Kendziorski, C.

Single-cell RNA-sequencing (scRNA-seq) has emerged as a revolutionary tool that allows us to address scientific questions that eluded examination just a few years ago. With the advantages of scRNA-seq come computational challenges that are just beginning to be addressed. In this article, we highlight the computational methods available for the design and analysis of scRNA-seq experiments, their advantages and disadvantages in various settings, the open questions for which novel methods are needed, and expected future developments in this exciting area.

Citation

Bacher, R., Kendziorski, C. "Design and computational analysis of single-cell RNA-sequencing experiments" Genome Biology (2016): 63